Advances in the synthesis of bromophenol compounds
10.13220/j.cnki.jipr.2018.04.001
- Author:
Ya-Fei WANG
1
Author Information
1. Key Laboratory of Marine Drugs, Ministry of Education, School of Medicineand Pharmacy, Ocean University of China
- Publication Type:Journal Article
- Keywords:
Biological activity;
Bromophenol natural products;
Innovative drugs;
Total synthesis
- From:
Journal of International Pharmaceutical Research
2018;45(4):245-252
- CountryChina
- Language:Chinese
-
Abstract:
Bromophenols are a class of natural products featuring novel chemical structures and diverse biological activities. These compounds possess anti-tumor,antibacterial and anti-oxidation activities,which has attracted much attention from synthetic chemists. Bromophenol derivatives are synthesized using bromination,methylation,reduction and alkylation,while the total synthesis of complex bromophenol-type natural products make use of aldol reaction,Wittig reaction,reduction amination as well as Curtius rear- rangement. This review summarizes the synthesis of bromophenol derivatives and complex bromophenol-type natural products,to pro- vide reference for their efficient research.
