The mechanism and research progress of obeticholic acid in the intervention of non-alcoholic fatty liver disease
10.13220/j.cnki.jipr.2019.06.004
- Author:
Liang-Yong JIANG
1
Author Information
1. Jiamusi University
- Publication Type:Journal Article
- Keywords:
Farnesoid X receptor;
Non-alcoholic fatty fiver disease;
Obeticholic acid
- From:
Journal of International Pharmaceutical Research
2019;46(6):423-426
- CountryChina
- Language:Chinese
-
Abstract:
Non-alcoholic fatty liver disease(NAFLD)is a relatively common chronic liver disease with imbal- anced lipid metabolism, and its incidence is increasing year by year. NAFLD is closely related to bile acid excretion, ab- normal bile acid synthesis and liver fibrosis. Farnesolid X receptor(FXR)regulates bile acid transport, inhibits bile acid synthesis and resists liver fibrosis. Obeticholic acid is a targeted drug for the treatment of NAFLD targeting the farnesol X receptor, which can effectively regulate fat metabolism and blood sugar balance. This review summarizes the mechanism and research progress of obeticholic acid intervention in NAFLD, and provides a theoretical basis for its foundamental re- search and clinical application.
