Improvement of the preparation process of Schisandrae Chinensis Fructus granules
10.13220/j.cnki.jipr.2019.07.012
- Author:
Hai-Bing LI
1
Author Information
1. Department of Pharmacy, The 908th Hospital of Chinese People’s Liberation Army Joint Logistic Support Force
- Publication Type:Journal Article
- Keywords:
Orthogonal test;
Preparation process;
Schisandrae Chinensis Fructus granules;
Schizandrin
- From:
Journal of International Pharmaceutical Research
2019;46(7):557-561
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To optimize the preparation process of Schisandrae Chinensis Fructus granules(SCFG) to obtain a stabilized and qualified SCFG-preparation. Methods: The Schisandrae Chinensis Fructus raw materials were extracted by decoction with water,and the extraction process was optimized by the orthogonal test. In the orthogonal test, the yield of total extract and the extraction rate of schizandrin were used as evaluation index,and the effect of solid-liquid ratio,decoction time and extraction times on the indexes were investigated to optimize the related parameters of these fac- tors. Meanwhile,the concentration process,drying process and granulation process were also investigated to finally opti- mize the preparation process of SCFG products. The content of schizandrin was determined by the HPLC method. Re- sults Under the HPLC conditions in the Pharmacopia of the People’s Republic of China(2015 edition),schizandrin showed a good linearity in the range of 0.03598-0.28784 μg(r=1.0000),with the average recovery rate 99.32% and RSD 2.17%. The conditions for the optimized extraction process were 3 times of extraction,with 0.5 h of each decoction time and with the 1:8,1:6 and 1:6 solid- liquid ratio in turn. The conditions for the optimized concentration process were concentrating at 60℃ and -0.08 MPa vacuum to a certain concentration. The conditions for the optimized drying pro- cess were drying at 60℃ and -0.09 MPa vacuum to a dryness. The conditions for the optimized granulation process were adding appropriate amount of dextrin,using 90% alcohol as moistening agent,and sifting with 14 mesh sieve and desic- cating at 60℃. Conclusion: The improved method is feasible,simple,stable and suitable for large-scale production of SCFG products.
