TGF-β1/Smad signaling pathway in tissue fibrosis:research advances
10.13220/j.cnki.jipr.2019.10.002
- Author:
Ping-Fen YANG
1
Author Information
1. Biomedical Engineering Research Center, Kunming Medical University
- Publication Type:Journal Article
- Keywords:
Hepatic fibrosis;
Myocardial fi- brosis;
Pulmonary fibrosis;
Renal fibrosis;
TGF-β1/Smad signal pathway
- From:
Journal of International Pharmaceutical Research
2019;46(10):738-744
- CountryChina
- Language:Chinese
-
Abstract:
Transforming growth factor-β1(TGF-β1)is an important factor in tissue fibrosis. TGF-β1 directly ac- tivates Smad signaling which triggers the overexpression of profibrotic genes. A large number of studies have shown that the dysregulation of TGF-β1/Smad pathway is an important pathogenic mechanism in tissue fibrosis. Smad2 and Smad3 are the two major downstream regulators that promote TGF-β1-mediated tissue fibrosis,whereas Smad7 acts as a nega- tive feedback regulator of the TGF-β1/Smad pathway,blocking TGF-β1-mediated fibrosis. In addition,the recent re- searches have shown that microRNA(miRNA)can regulate the TGF-β1/Smad signaling pathway,and affect the process of tissue fibrosis. This article reviews the role of TGF-β1/Smad signaling pathway in renal,hepatic,pulmonary and myo- cardial fibrosis,as well as the regulation of TGF-β1/Smad signaling pathway by miRNA.
