Organic anion transporting polypeptides:research advances
10.13220/j.cnki.jipr.2019.11.002
- Author:
Cong-Yang DING
1
Author Information
1. Graduate School of Hebei Medical University
- Publication Type:Journal Article
- Keywords:
Distribution;
Influenc- ing factors;
Organic anion transporting polypeptides;
Regulation mechanism;
Subtypes
- From:
Journal of International Pharmaceutical Research
2019;46(11):813-819
- CountryChina
- Language:Chinese
-
Abstract:
By reviewing the relevant domestic and foreign literature of organic anion transporters(organic anion transporting polypeptides,OATP),the research on subtypes,regulation mechanisms,distribution,effect and influenc- ing factors of OATP is summarized. OTAP acts as a transporter widely distributed in humans and rodents,and their pro- tein structure is not exactly the same in different species. There are also differences in the distribution of OTAP in various organs in the same species,and the ability of OTAP to transport substances is different. When multiple drugs or foods are taken at the same time,they may interact through OATP,resulting in the decreased efficacy and increased adverse reac- tions of drugs. More research is needed on the exploration of OATP subtypes and mechanisms.
