The endothelial-mesenchymal transition in glioma and strategies for targeted therapy: research progress

VernacularTitle: 内皮间质转化在胶质瘤中的研究现状及其靶向治疗策略
Author: Hai-Hong CAO ¹
Author Information

1. School of Traditional Chinese Medicine, Southern Medical University
Publication Type:Journal Article
Keywords: Endothelial-mesenchymal transition(EndoMT); Glioma; Signaling pathway; Therapeutic target
From: Journal of International Pharmaceutical Research 2020;47(4):243-250
CountryChina
Language:Chinese
Abstract: Endothelial-mesenchymal transition(EndoMT)is a pathophysiological progress that endothelial cells lose their specific phenotype,function and morphology and gradually transform to mesenchymal cells under the effect of certain stimulating factors. More and more researches have shown that EndoMT plays a key role in the occurrence and development as well as the invasion and metastasis of glioma. This paper reviews the EndoMT-related signaling pathways and their important effect on the angiogenesis,invasion,metastasis,immunosuppression and the drug resistance of glioma. Meanwhile, strategies for the EndoMT-targeted therapy are also summarized, so as to provide a reference for related studies and clinical treatment of glioma.