The pH low insertion peptides and their application: research advances
10.13220/j.cnki.jipr.2020.08.002
- VernacularTitle: 酸响应肽及其应用研究进展
- Author:
Ying SUN
1
Author Information
1. Inner Mongolia Key Laboratory of Molecular Biology, Inner Mongolia Medical University
- Publication Type:Journal Article
- Keywords:
Extracellular acidic environment;
Imaging;
Nanotechnology;
PH low insertion peptides
- From:
Journal of International Pharmaceutical Research
2020;47(8):589-593
- CountryChina
- Language:Chinese
-
Abstract:
Many diseases such as tumor, ischemia and inflammation produce acidic extracellular microenvironment at the lesion site. This extracellular microenvironment also provides a new opportunity for the diagnosis and treatment of these diseases. Acidresponding peptides (pH low insertion peptides, pHLIP) can spontaneously fold into transmembrane helices under acidic microenvironment and insert across cell membranes, providing new opportunities for targeting these acidic tissues. At present, pHLIP has attracted more and more attention in the diagnosis and treatment of diseases. This article summarizes the advances in the pHLIP research from the aspects of the discovery and development, action mechanism and application of pHLIP.
