Occurrence characteristic of Kashin-Beck Disease based on nuclear family pedigrees
- Author:
Xiong GUO
1
Author Information
1. Institute of Endemic Diseases
- Publication Type:Journal Article
- From:Academic Journal of Xi'an Jiaotong University
2003;15(1):34-37
- CountryChina
- Language:Chinese
-
Abstract:
Objective: The occurrence characteristic of Kashin-Beck Disease (KBD) in pedigrees ascertained on the basis of one proband was estimated. Methods: A total of 255 individuals in 40 pedigrees were collected from areas in the Shaanxi Province. Results: (1) Parents and siblings of index cases have a 3-4 times higher risk than a randam unrelated individual. The odds ratio for disease is higher in mothers than in fathers of index cases; (2) Prevalence in relatives of index cases (Kr = 59.2%) greatly exceeds population prevalence (K = 17.5%); (3) Kr increases with sibship size; (4) There is no significant difference of Kr for male and female siblings of index cases. Also, population prevalence is not sex-specific. Conclusion: In conjunction with invironmental agents, genetics may play an important role in KBD etiology.
