Effect of capsaicin on substance P in psoriasis vulgaris
- Author:
Wanjuan WANG
1
Author Information
1. Department of Dermatology
- Publication Type:Journal Article
- From:Academic Journal of Xi'an Jiaotong University
2003;15(2):199-201
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To the investigate the mechanism of capsaicin in psoriasis vulgaris. Methods: Substance P (SP) in psoriatic lesions before and 6 weeks after the treatment with capsaicin was detedted by radioimmunoassary. Results: After 3 weeks and 6 weeks treatment with capsaicin, SP in psoriatic lesions was decreased (P<0.05), while it in the self-control group was not decreased; Overall the efficient incidence in therapeutic group was 78.8%, while it in the control group was 36.8%. There was significant difference between them (χ2 = 16.30, P < 0.001). Conclusion: Capsaicin inhibits dermal inflammatory responses and proliferation of keratinocytes by decreasing the expression of SP in psoriasis vulgaris.
