Effect of ABCA1-V771M polymorphism on plasma lipid levels and its relationship with coronary atherosclerotic heart disease
- Author:
Dongqi WANG
1
Author Information
1. Department of Cardiology
- Publication Type:Journal Article
- Keywords:
ATP-binding cassette transportera A1 (ABCA1);
Chinese population;
Coronary heart disease;
High density lipoprotein cholesterol;
Single nucleotide polymorphisms
- From:Academic Journal of Xi'an Jiaotong University
;20(2):82-87
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the risk association of ABCA1-V771M polymorphism with coronary heart disease (CHD) in Han nationality in Northwest of China. Methods With case-control study, ABCA1-V771M polymorphism was detected in 204 unrelated Han nationality people in Northwest of China, and all the subjects by coronary angiography were grouped into 106 cases and 98 controls. The genotypes and alleles frequency distribution of ABCA1-V771M polymorphisms were analyzed by PCR-RFLP analysis, and the clinical statistics of serum lipids were compared and its effects of ABCA1-V771M polymorphism on the plasma lipid levels and coronary atherosclerotic heart disease were analyzed. Results: The genotypic frequencies of ABCA1-V771M polymorphism matched well under Hardy-Weinberg equilibrium (P>0.05), V and M allelic frequencies were 33.3% and 66.7%. In comparison with VV+VM genotype carriers, MM genotypes carriers had much lower plasma levels of HDL-C (P<0.001) and much higher plasma levels of TG (P<0.05). M allelic frequency in CHD group was significantly higher than V allelic frequency (P<0.05). M allele was related with more severity of atherosclerosis in the coronary artery than V allele (P<0.05). However, there was no obvious difference in the incidence of AMI among carriers with three genotypes of ABCA1-V771M polymorphism (P>0.05). Conclusion: ABCA1-V771M polymorphism was not only associated with the plasma levels of HDL-C and TG, but also related to the susceptibility and severity of coronary atherosclerotic heart disease. Moreover, M771 allele appeared to be atherogenic among Han population in Northwest of China.
