Capillary electrophoresis coupled with electrochemiluminescence for determination of cloperastine hydrochloride
- Author:
Fengmei XIONG
1
Author Information
1. Institute of Analytical Sciences
- Publication Type:Journal Article
- Keywords:
Capillary electrochemiluminescence;
Cloperastine hydrochloride;
Tris-(2,2′-bipyridyl) ruthenium (II)
- From:Academic Journal of Xi'an Jiaotong University
;20(4):274-277
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the electrochemiluminescence (ECL) behavior of cloperastine hydrochloride. Methods: ECL intensity of tris (2,2′-bipyridyl) rutheniumo(II) was enhanced, the method for the determination of cloperastine hydrochloride was established using capillary electrophoresis (CE) coupled with electrochemilumolinescence (ECL) detection. Results: Under the optimum conditions, ECL intensity varied linearly with cloperastine hydrochloride concentration from 7.0 × 10-6g/mL to 1.0 × 10-4g/mL. The detection limit (S/N=3) was 8.05 × 10-7 g/mL. The relative standard deviation of the ECL intensity and the migration time for 11 consecutive iajections of 1.0 × 10-5 g/mL cloperastine hydrochloride was 2.9% and 1.5%, respectively. This method was successfully applied to cloperastine hydrochloride tablet determination. Conclusion: The method has been established, validated and applied for determination of cloperastine hydrochloride.
