Flow-injection-enhanced chemiluminescence method for the determination of three β-blockers
- Author:
Li-Juan WANG
1
Author Information
1. Institute of Analytical Sciences
- Publication Type:Journal Article
- Keywords:
β-blocker;
Chemiluminescence;
Flow-injection
- From:Academic Journal of Xi'an Jiaotong University
2010;22(2):91-96
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To develop a rapid, simple and sensitive chemiluminescence method for the determination of three β-blockers (bisoprolol, atenolol and propranolol). Methods: The chemiluminescence of cerium (IV)-sulfite system was obviously sensitized by adding anyone of three β-blockers in acid media. A new chemiluminescence method was set up by combining with flow-injection technique and used to determine the three β-blockers. Results: Good linear ranges were obtained at the concentrations of 2.0×10-7g/mL-4. 0×10-5g/mL, 1.0×10-7g/mL-3.0×10 -5g/mL and 7.0×10-7g/mL-1.0×10 -5g/mL, respectively, with the detection limits of 5.0×10 -8g/mL, 7.0×10-8g/mL and 5.0×10 -8g/mL (S/N= 3), respectively, and the relative standard deviations for 11 times consecutive injections of 1.0×10-5g/mL bisoprolol, atenolol and propranolol were 3.57%, 2.21% and2.26%, respectively. Conclusion: The developed method is sensitive, accurate, rapid and of low cost. And it can be applied to determine bisoprolol, atenolol and propranolol in pharmaceutical preparations.
