Effects of cerebral cortical concis on cell proliferation of the subventricular zone in adult rats
- Author:
Yuelin ZHANG
1
Author Information
1. Department of Huma Anatomy, Histology and Embryology
- Publication Type:Journal Article
- From:Academic Journal of Xi'an Jiaotong University
2006;18(2):191-194
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the proliferative response and time course of endogenous neural stem/ progenitor cells after cerebral cortical concis in the adult rats. Methods: Eighty adult male Sprague-Dawley rats were used in this study. Cumulative BrdU labeling was employed to detect the proliferating cells. At 1 d, 3 d, 7 d, 14 d, and 21 d after cerebral cortical concis, the rats were killed for BrdU immunohistochemical staining and cell counting in the injured ipsilateral SVZ. Results: Little BrdU immunoreactivity cells was present in SVZ of the control rats from day 7 to day 21 after sham operation. The number of BrdU immunoreactivity cells in the injured ipsilateral SVZ increased at day 1 and peaked at day 7 after cerebral cortical concis. Conclusion: After cerebral cortical concis of the adult rats, neural stem/progenitor cells in the injured ipsilateral SVZ markedly proliferated with a peak at day 7. This finding may be important for manipulating SVZ cells to promote the recovery from cerebral cortical concis.
