Reducing intimal hyperplasia in vein grafts harvested by a no-touch harvesting technique
- Author:
Hai-Chen WANG
1
Author Information
1. Department of Cardiovascular Surgery
- Publication Type:Journal Article
- Keywords:
Intimal hyperplasia;
No-touch harvesting technique;
Vein graft
- From:Academic Journal of Xi'an Jiaotong University
2009;21(2):138-140
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effect of no-touch harvesting technique in reducing vein graft intimal hyperplasia. Methods: This longitudinal trial compared graft angiostenosis of two groups undergoing jugular vein to carotid artery interposition grafting in rabbit model. Conventional group: 12 rabbits had their veins stripped, distended, and stored in heparinized saline solution. No-touch group: 12 rabbits had veins removed with surrounding tissues, but were not distended, and stored in heparinized blood. The grafts were removed 4 weeks following grafting, and morphometry and immunohistochemistry assessment were performed. Results: The intimai thickness, degree of angiostenosis and proliferation index of vascular smooth muscle cells of no-touch group were significantly reduced (P<0.01) compared with those of the conventional group. The proliferating cell nuclear antigen positive-staining cells were significantly increased (P<0.01) in the conventional group compared with whose in the no-touch group. Conclusion: Harvesting the vein graft with no-touch harvesting technique could significantly reduce intimai hyperplasia of the vein graft.
