Recent progress on the mechanism of energy metabolism of hypoxia-inducible factor 1-driven skeletal muscle adaptations to hypoxia
10.16098/j.issn.0529-1356.2017.02.021
- Author:
Ya-Qiong SONG
1
Author Information
1. Department of Anatomy, Zunyi Medical College
- Publication Type:Journal Article
- Keywords:
Energy metabolism;
Hypoxia;
Hypoxia-inducible factor 1;
Skeletal muscle
- From:
Acta Anatomica Sinica
2017;48(2):236-240
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia-inducible factor 1 (HIF-1) is a key nuclear transcription factor that regulates the oxygen homeostasis of tissue cells and widely exists in both mammals and humans. The expression and activity of HIF-1 are tightly regulated by cellular oxygen concentration. It can regulate the biological effects of cellular energy metabolism, angiogenesis, erythropoiesis, cell survival, cell proliferation and apoptosis in the physiological and pathological hypoxicischemic condition, so that the cells can adapt to the hypoxic environment to survive, or to apoptosis. This paper reviewed the structure and function of HIF-1 and the recent progress on the study of the mechanism of energy metabolism of HIF-1 - driven skeletal muscle adaptations to hypoxia.
