Progress of mechanism and therapy on cerebral vasospasm after subarachnoid hemorrhage
10.16098/j.issn.0529-1356.2019.04.023
- Author:
Si-Qi LIU
1
Author Information
1. Department of Emergency, Peking University, People's Hospital
- Publication Type:Journal Article
- Keywords:
Brain injury;
Cerebral vasospasm;
Stroke;
Subarachnoid hemorrhage
- From:
Acta Anatomica Sinica
2019;50(4):537-542
- CountryChina
- Language:Chinese
-
Abstract:
Subarachnoid hemorrhage (SAH) accounts for about 5% of all stroke patients, with high disability and mortality. Secondary cerebral vasospasm (CVS) after SAH interrupts cerebral blood flow to important parts of the brain, and then causes cerebral ischemia, which is one of the major complications of the disability and mortality. CVS usually occurring 3 to 12 days after SAH and lasted for an average of two weeks. The mechanism of CVS after SAH is very complex, and it is a process involving multiple factors and links, including hemolysis products, imbalance of vasodilator and vasoconstrictors, inflammation, activation of signal cascade reaction, apoptosis and expression of related genes. The treatment of CVS after SAH is divided into interventional therapy and drug therapy. Effective prediction, prevention, and treatment of CVS will significantly improve survival and quality of life after SAH. This article briefly reviews progress of the research on the mechanism and treatment of cerebral vasospasm after SAH.
