Mechanisms and effects of PM2.5 on diseases of respiratory system: Latest findings

Author: Jian-Hua YI ¹
Author Information

1. School of Public Health, Xi'an Jiaotong University Health Science Center
Publication Type:Journal Article
Keywords: Cell apoptosis; Cell autophagy; Genetic toxicity; Inflammatory reaction; Oxidative stress; PM2.5; Respiratory disease
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2019;40(1):167-172
CountryChina
Language:Chinese
Abstract: The chemical composition of PM2.5 is extremely complex and it can carry some viruses and bacteria, gather many toxic and hazardous substances. The respiratory system is the main target organ of PM2.5 exposure and impact. There are many different kinds of respiratory system diseases, which have complex etiologies and unpredictable outcomes. Previous reports have shown that PM2.5 plays an important role in the occurrence and development of respiratory obstructive, infectious, allergic and neoplastic diseases; of which mechanisms may be related to oxidative stress, inflammatory reaction, genetic toxicity, cell apoptosis, cell autophagy and cell cycle disorders.