Pharmacological effects of the active ingredient genkwanin in Leonurus on coagulation and anti-inflammation in mice
- Author:
Jiang-Bo FAN
1
Author Information
- Publication Type:Journal Article
- Keywords: Anti-inflammatory effect; Genkwanin; Leonurus
- From: Journal of Xi'an Jiaotong University(Medical Sciences) 2019;40(1):158-161
- CountryChina
- Language:Chinese
- Abstract: Objective: To investigate the pharmacological effects of genkwanin, the active ingredient in Leonurus on coagulation and anti-inflammation in mice. Methods: The body torsion pain caused by acetic acid model, auricle swelling induced by xylene, and the blood capillary permeability model were used to investigate the analgesic and anti-inflammatory effects of genkwanin in mice. Results: The clotting time was significantly reduced in medium- and high-dose genkwanin groups compared with the control group (P<0.05). The times of mice's body torsion pain caused by acetic acid was significantly reduced at 10 minutes after administration in the large-dose group compared with the control group (P<0.01). Compared with the model group, the positive control (aspirin) group had a significant difference (P<0.01) in the difference value of left- and right-ear weights, the high-dose group had significant difference (P<0.05). In the experiment on the influence of genkwanin on blood capillary permeability of the mice abdominal cavity, compared with the model group, a marked decrease of A value (P<0.01) was found in the positive control group, but there was no significant difference of A value (P>0.05) in the low-dose genkwanin group, a significant reduce of A value (P<0.05) in the medium-dose group, and an extremely significant decrease of A value (P<0.01) in the high-dose group. Conclusion: Genkwanin can promote blood coagulation function of mice, and reduce the times of their body torsion pain caused by acetic acid, showing obvious analgesic effects. Furthermore, genkwanin can inhibit auricle swelling of mice induced by xylene and reduce the blood capillary permeability of their abdominal cavity, suggesting its mild anti-inflammatory effects. The findings can provide clinical evidence for treating dysmenorrheal and endometritis.
