Clinicopathological features of gastric cancer in 108 young patients
- Author:
Cai-Wen LI
1
Author Information
- Publication Type:Journal Article
- Keywords: Age; Clinical; Gastric cancer; Pathological feature; Prognosis
- From: Journal of Xi'an Jiaotong University(Medical Sciences) 2019;40(6):922-926
- CountryChina
- Language:Chinese
- Abstract: Objective: To evaluate the clinicopathological and prognostic features of young patients with gastric cancer. Methods: We retrospectively analyzed the age trend of all the inpatients gastric with adenocarcinoma pathologically confirmed from 2012 to 2017 in our institution. The cut-off value of 45 years old to distinguish the young and the middle-aged patients with gastric cancer was defined to be the bottom fifth percentile in the age histogram of all gastric cancer patients. Then we analyzed the demographic, clinicaopathological, molecular pathological and prognostic features of the two groups. Results: Based on the age and gender composition of the gastric cancer patients, 45 years was defined as the cut-off age to differentiate the young (n=108) and the middle-aged gastric (n=216) cancer patients. The gender ratio was 1.4:1 and 3.5:1 in the young group and the middle-aged group, respectively (P<0.001). Although there was no statistical significance, family history was much more in the young group than in the middle-aged Group (8.33% vs. 2.78%, P=0.062). Otherwise, those young patients always had some distinct features, including delay in diagnosis, primarily in antrum and frequent multifocal sites compared with the middle-aged gastric cancer patients. Furthermore, we found more frequent occurrence of gastric ulcer history, poorly differentiated adenocarcinoma and signet-ring cell carcinoma, Borrmann III and typing, and diffuse typing in the young patients. Moreover, less radical gastrectomy and shorter survival were also exhibited (P<0.05). Surprisingly, ER and PR were not detected within gastric cancer tissues with IHC (P>0.05). Conclusion: The young patients with gastric cancer exhibits different behavior and can be considered as a unique clinical entity. Further studies are required to fully understand the possible carcinogenesis and risk factors among young gastric cancer patients.
