Osteoprotegerin is an independent risk factor for coronary calcification in patients with hypertension and is associated with angiotensin Ⅱ
- Author:
Jia-Yu DIAO
1
Author Information
- Publication Type:Journal Article
- Keywords: AngiotensinⅡ; Coronary artery calcification; Hypertension; Osteoprotegerin
- From: Journal of Xi'an Jiaotong University(Medical Sciences) 2019;40(6):911-915
- CountryChina
- Language:Chinese
- Abstract: Objective: To evaluate the relationship between plasma osteoprotegerin (OPG) level and coronary artery calcification in patients with hypertension and the relationship between OPG and angiotensin Ⅱ (AngⅡ). Methods: A total of 348 patients with hypertension were enrolled in this study. Coronary calcification was determined by 64-row coronary CT. Patients with hypertension were divided into coronary calcification group and non-coronary calcification group according to their coronary calcification score. We compared the clinical and laboratory indications of the two groups. The odds ratio (OR) value of risk factors for coronary calcification and the correlation coefficient between OPG and AngⅡ levels were calculated. Results: The OPG and AngⅡ levels in patients with coronary calcification were higher than those in patients without coronary calcification (P<0.001). Multivariate logistic regression analysis showed that OPG level (OR 3.728, 95% CI 1.314-7.714) and AngⅡ level (OR 2.385, 95% CI 1.281-4.836) were both independent risk factors for coronary calcification (P<0.001). Moreover, OPG and AngⅡ levels were both correlated with the severity of coronary artery calcification. In patients with coronary calcification, OPG level was positively correlated with AngⅡ level (r=0.509, P<0.001), while in patients without coronary calcification, OPG level was not correlated with AngⅡ level (P>0.05). Conclusion: OPG is an independent risk factor for coronary artery calcification in patients with hypertension and is related to the severity of coronary artery calcification. In hypertensive patients with coronary artery calcification, OPG and AngⅡ levels are positively correlated.
