Changes of working memory function and its risk factors in end-stage renal disease patients
- Author:
Xueying MA
1
Author Information
- Publication Type:Journal Article
- Keywords: End-stage renal disease; N-back; Risk factor; Uremic toxin; Working memory
- From: Journal of Xi'an Jiaotong University(Medical Sciences) 2020;41(2):182-187
- CountryChina
- Language:Chinese
- Abstract: Objective: To explore the changes of working memory function and its risk factors in end-stage renal disease (ESRD) patients. Methods:We prospectively recruited 30 ESRD patients without dialysis and 23 healthy controls in The First Affiliated Hospital of Xi'an Jiaotong University from August 2016 to December 2017. The n-back working memory task with different loads was used to assess their working memory function; the general information of all the participants, arterial blood pressure and uremic toxins of the patients were collected to analyze the risk factors of working memory changes. Results: The reaction time of working memory with different loads was significantly longer than that in the healthy controls (P<0.01), and the accuracy of 1-back was lower than that in the healthy controls (P<0.01). With the increase of memory load, the reaction time was increased while the accuracy was decreased. The interaction between n-back working memory load and grouping was not significant (P>0.05). The correlation analysis showed that serum creatinine, blood urea nitrogen and parathyroid hormone levels were negatively correlated with the accuracy rate of working memory with different loads (P<0.05). Conclusion: The working memory function with different loads was impaired in ESRD patients. The accumulation of uremic toxins might be the risk factor for the working memory impairment in ESRD patients.
