Temozolomide resistance in high grade gliomas
10.3969/j.issn.1674-8115.2018.01.022
- Author:
Xiang-Yu WEI
1
Author Information
1. Department of Neurosurgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
- Publication Type:Journal Article
- Keywords:
High grade glioma;
Mismatch repair;
O6-methylguanine-DNA methyltransferase;
Resistance;
Temozolomide
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2018;38(1):117-124
- CountryChina
- Language:Chinese
-
Abstract:
High grade gliomas are always the research focus in the field of neurosurgery due to their poor prognosis despite the current standard therapeutic regimen of surgical resection followed by radiation therapy and chemotherapy. Alkylating agent temozolomide has been established as the standard chemotherapy while its resistance inevitable during treatment. This phenomenon seriously influences the prognosis of patients suffering from high grade gliomas. This review aims to elucidate temozolomide chemoresistance mechanisms through three chapters including O6-methylguanine-DNA methyltransferase (MGMT) methylation, mismatch repair mutation and epigenetic regulation consisting of p21, chromatin and histone, Y-box binding protein-1 and microRNAs.
