Vaccine strategies in prevention and treatment of atherosclerosis
10.3969/j.issn.1674-8115.2018.01.021
- Author:
Yu-Chen XUE
1
Author Information
1. Department of Anesthesiology and SICU, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
- Publication Type:Journal Article
- Keywords:
Atherosclerosis;
Cholesterol ester transfer protein;
Immunization;
Vaccine
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2018;38(1):108-111
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis is an immune-mediated inflammatory disease of the arterial wall, with both the innate and adaptive immune systems responding to many endogenous and exogenous antigens. Both proatherogenic as well as atheroprotective roles have been identified for the immune system in atherosclerosis. Hence, it is conceivable that an immuno-modulatory strategy via active immunization against many of these antigens could potentially alter the natural history of atherosclerosis. Cholesterol ester transfer protein (CETP) plays an important role in lipid metabolism, suggesting it might prevent atherosclerosis. This review discusses the recent advances of vaccine targeting the development of atherosclerosis, mainly about the CETP targeting vaccines.
