Principle and applications of fluorescent probes for intracellular redox detection
10.3969/j.issn.1674-8115.2018.01.020
- Author:
Ao LIU
1
Author Information
1. Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation
- Publication Type:Journal Article
- Keywords:
Fluorescent probe;
Genetic coding fluorescence probe;
Reactive oxygen species;
Redox
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2018;38(1):101-107
- CountryChina
- Language:Chinese
-
Abstract:
Redox state indicated by reactive oxygen species (ROS) level is a cellular physiological feature. Redox status is exactly controlled by conserved system. Its alterations consequently modulate various biological activities and play important roles in cells and organism under physiological and pathological conditions. Hence detection of redox state is deemed as an important technique both in basic and clinical researches. The present article reviews the principle and current applications of fluorescent probes or sensors for redox detection. With comparison of properties of various probes, especially genetic coding fluorescence probes, much understanding will be gained. And the review helps us to understand how to apply the redox probes on the biological and clinical researches and eventually look forward to new applications in the cell and whole animal level.
