Preliminary screening and study of novel flavonoid monoacylglycerol lipase inhibitors
10.3969/j.issn.1674-8115.2018.01.006
- Author:
Jia-Hui MA
1
Author Information
1. Department of Chemistry, Shanghai Jiao Tong University College of Basic Medical Sciences
- Publication Type:Journal Article
- Keywords:
Flavonoids;
Inhibitor;
Monoacylglycerol lipase
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2018;38(1):30-35
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To discover and develop novel monoacylglycerol lipase (MAGL) inhibitors. Methods: Computational screening, rational structure analysis and biological assessment was used. Results: A series of natural flavonoid MAGL inhibitors were identified. Compound 9 (quercetin) presented the highest activity with an IC50 value of 36 μmol/L. Conclusion: Several natural flavonoid MAGL inhibitors were identified, which are expected to bring novel hits for discovery of MAGL inhibitors.
