The clinical significance of the differernce in left ventricular ejection fraction between rest and stress on gated myocardial perfusion SPECT.
- Author:
Jae Kook SHIN
1
;
Hyeon Min RYU
;
Jang Hoon LEE
;
Byoung Jin CHANG
;
Yong Seop KWON
;
Hyun Sang LEE
;
Seung Chul SHIN
;
Hyung Seop KIM
;
Jeong Ho HEO
;
Dong Heon YANG
;
Byeong Cheol AHN
;
Hun Sik PARK
;
Yong Keun CHO
;
Shung Chull CHAE
;
Jae Eun JUN
;
Wee Hyun PARK
Author Information
1. Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea. hspark@knu.ac.kr
- Publication Type:Original Article
- Keywords:
Gated myocardial perfusion SPECT;
Myocardial stunning;
Coronary artery stenosis
- MeSH:
Constriction, Pathologic;
Coronary Angiography;
Coronary Artery Disease;
Coronary Stenosis;
Electrocardiography;
Humans;
Hyperlipidemias;
Myocardial Ischemia;
Myocardial Stunning;
Perfusion*;
Retrospective Studies;
Stroke Volume*;
Tomography, Emission-Computed, Single-Photon*
- From:Korean Journal of Medicine
2005;68(3):277-283
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Gated myocardial perfusion SPECT improved diagnostic accuracy of coronary artery disease and enabled us to observe motion and thickening of myocardial walls, ejection fraction as well as myocardial perfusion. Many studies suggested that there was a decrease of left ventricular ejection fraction (LVEF) at post-stress compared with that at rest gated myocardial perfusion SPECT (stunning). The objective of this retrospective study is to evaluate the clinical significance of the decrease of LVEF at post-stress gated myocardial perfusion SPECT by correlating with coronary angiographic finding. METHODS: Authors selected 41 patients who underwent exercise electrocardiography and gated myocardial perfusion SPECT between May, 2001 and May, 2002. The patients underwent coronary angiography within 6 months. The patients were divided into two groups, 16 patients in whom post-stress LVEF was >or=5% lower than rest (stunning group) and 25 patients in whom LVEF was not >or=5% lower than rest (non-stunning group). RESULTS: The number of patients with hyperlipidemia was higher in stunning group than in non-stunning group (50% vs 4%, p=0.001). The number of patients with angiographic stenoses >90% was significantly higher in stunning group than in non-stunning group (75% vs 28%, p=0.04). The number of patients with multi-vessel disease was also significantly higher in stunning group than in non-stunning group (75% vs 36%, p=0.015). CONCLUSION: The patients who had a decreased LVEF after stress (stunning) showed more severe coronary artery stenosis. This finding suggests that stunning may be an important additional indicator of underlying myocardial ischemia.
