Progress on prophylactic medicine against platinum-based ototoxicity in children with solid tumor
10.3969/j.issn.1674-8115.2018.03.022
- Author:
Meng WEI
1
Author Information
1. Department of Pediatric Hematology/Oncology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
- Publication Type:Journal Article
- Keywords:
Children;
Ototoxicity;
Platinum compounds;
Prevention
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2018;38(3):357-360
- CountryChina
- Language:Chinese
-
Abstract:
Platinum compounds are crucial chemotherapy drugs for children with solid tumor, and the ototoxicity is one of the dose-limiting toxicities. Platinum-induced hearing loss is detrimental to language learning and social development especially for children. Several clinical trials of drugs against platinum-based ototoxicity have been carried out, the results prompted that sodium thiosulfate, amifostine and N-acetylcysteine potentially reduce the occurrence risk of hearing loss. Without affecting the therapeutic effect, preventive use of antagonists on platinum-based ototoxicity will improve the life quality and treatment compliance of pediatric patients with tumor.
