Role of SUMO-specific proteases in tumor biological behavior
10.3969/j.issn.1674-8115.2018.03.020
- Author:
Hui-Xian MIAO
1
Author Information
1. Shanghai Jiao Tong University School of Medicine
- Publication Type:Journal Article
- Keywords:
SUMO;
SUMO-specific proteases (SENPs);
Tumor
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2018;38(3):348-352
- CountryChina
- Language:Chinese
-
Abstract:
SUMOylation is a dynamically reversible process that needs to be modified by a specific ligase, while its inverse reaction deSUMOylation is catalyzed by a group of SUMO-specific proteases (SENPs). SUMO-modified target protein molecules are closely related to development and disease, especially tumor, metabolism, inflammation and immunity. SENPs play an important role in SUMO protein maturation and deSUMOylation. This review discussed the functions of SENPs in the development and progression of tumors and related mechanisms.
