Polymorphisms of interleukin-1beta and interleukin-1 receptor antagonist genes in patients with pulmonary tuberculosis.
- Author:
Doo Soo JEON
1
;
Jae Hyung LEE
;
Su Jin LEE
;
Woo Hyun JO
;
Kyung Sik JEONG
;
Ki Wook KIM
;
Yun Seong KIM
;
Min Ki LEE
;
Young Dae KIM
;
Young Min CHOI
;
Seung Kyu PARK
;
Soon Kew PARK
Author Information
1. Department of Internal Medicine, Pusan National University College of Medicine, Busan, Korea. yskimdr@yahoo.co.kr
- Publication Type:Original Article
- Keywords:
Interleukin-1;
Polymorphism;
Tuberculosis
- MeSH:
Alleles;
Genotype;
Heterozygote;
Humans;
Interleukin 1 Receptor Antagonist Protein;
Interleukin-1*;
Interleukin-1beta*;
Mycobacterium tuberculosis;
Polymerase Chain Reaction;
Tuberculosis;
Tuberculosis, Multidrug-Resistant;
Tuberculosis, Pulmonary*
- From:Korean Journal of Medicine
2005;68(3):284-291
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Several lines of evidence suggest that host genetic factors influence the outcome of exposure to Mycobacterium tuberculosis. The aim of this study was to determine whether polymorphisms in interleukin-1beta (IL-1beta) and Interleukin-1 receptor antagonist (IL-1Ra) genes associate with the susceptibility or resistance to pulmonary tuberculosis in Korean. METHODS: IL-1beta and IL-1Ra gene polymorphism were investigated in 60 drug sensitive (DS) and 100 multidrug-resistant (MDR) pulmonary tuberculosis cases, and 96 healthy controls. IL-1beta-511/-31/+3954 and IL-1Ra genotype were determined by polymerase chain reaction. RESULTS: Allelic and genotypic frequencies of IL-1beta-511/-31/+3954 showed no significant difference in 3 groups. IL-1Ra allele 2 heterozygotes were less frequent in DS (p=0.03, OR=0.26, 95% CI 0.07 to 0.95) and MDR tuberculosis (p=0.008, OR=0.26, 95% CI 0.09 to 0.75) than controls, but there was no significant difference between DS and MDR tuberculosis (p=1.00). CONCLUSION: IL-1Ra allele 2 heterozygote may be associated with resistance to pulmonary tuberculosis in Korean. Further studies will be required to confirm whether these results are of biologic significance.
