Role of phosphoglycerate mutase 1 in the occurence and development of tumor
10.3969/j.issn.1674-8115.2018.04.021
- Author:
Qian LIANG
1
Author Information
1. Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University, School of Medicine
- Publication Type:Journal Article
- Keywords:
2-phosphoglycerate;
3-phosphoglycerate;
Aerobic glycolysis;
Phosphoglycerate mutase 1
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2018;38(4):463-466
- CountryChina
- Language:Chinese
-
Abstract:
Phosphoglycerate mutase 1 (PGAM1) as one of the most important enzymes for glycolysis pathway, is highly expressed in multiple tumor tissues and negatively correlated with the prognosis of cancer patients. PGAM1 catalyzes the conversion of 3-phosphoglycerate (3-PG) to 2-phosphoglycerate (2-PG) in glycolysis pathway, then promoting anabolic pathways, energy generation, and maintaining redox balance during cancer cell proliferation and metastasis. The small molecule PGAM1 inhibitors have emerged as a promising strategy for anti-tumor therapy. In this review, the significance of PGAM1 in tumor was reviewed and the research progress of PGAM1 inhibitors was also introduced.
