Development of vaccines for prevention of Klebsiella pneumoniae
10.3969/j.issn.1674-8115.2018.04.020
- Author:
Guang-Xi WU
1
Author Information
1. Department of Anesthesiology and SICU, Xin Hua Hospital, Shanghai Jiao Tong University
- Publication Type:Journal Article
- Keywords:
Drug resistant;
Immune therapy;
Klebsiella pneumoniae;
Vaccine
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2018;38(4):458-462
- CountryChina
- Language:Chinese
-
Abstract:
Klebsiella pneumoniae is the most common cause of nosocomial respiratory tract, and the second most frequent cause of Gram-negative bacteraemia and urinary tract infections. Drug resistant isolates remain an important hospital-acquired bacterial pathogen, prolong hospital stays, and are especially problematic in high impact medical areas such as intensive care units. A variety of preventive measures were applied to reduce such incidences. The immune therapies for Klebsiella pneumoniae include active immunization and passive immunization. Many trials for constructing effective vaccines are followed, including inactivated vaccines, polysaccharide vaccine, conjugate vaccine, protein vaccine, and nano vaccine. This review was about the development of vaccines for the prevention of Klebsiella pneumoniae.
