Research advances in acetylation modification of α-synuclein in Parkinson's disease
10.3969/j.issn.1674-8115.2018.11.020
- Author:
Xiao YANG
1
Author Information
1. Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Publication Type:Journal Article
- Keywords:
Acetylation modification;
Aggregation;
Parkinson's disease (PD);
Α-synuclein
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2018;38(11):1381-1385
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease (PD) is an incurable neurodegenerative disease, which seriously affects the life quality of patients. Researches in recent years found that excessive production or abnormal structure of α-synuclein and forming toxic aggregates are the key factors in the pathogenesis of PD. In a variety of mechanisms, abnormal modification of α-synuclein is closely related to its aggregation state, such as phosphorylation, ubiquitination and nitration modification, but the exact effects are still uncertain. Recent studies have shown that acetylation modification of α-synuclein plays an important role in the abnormal aggregation of α-synuclein. This article reviewed the progress of acetylation modification of α-synuclein.
