Adult Onset Still's Disease Developed in a Patient with Membranous Nephropathy Treated with Immunosuppressive Agent.
- Author:
Hyo Jin KANG
1
;
Joon Mo KIM
;
So Young PARK
;
Sang Yeob LEE
;
Ki Hyun KIM
;
Seong Eun KIM
;
Young Ki SON
;
Won Suk AN
Author Information
1. Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea. anws@dau.ac.kr
- Publication Type:Case Report
- Keywords:
Adult onset still's disease;
Membranous nephropathy;
Immunosuppressive agent
- MeSH:
Adult;
Anti-Bacterial Agents;
Arthritis;
Connective Tissue Diseases;
Cyclosporine;
Exanthema;
Female;
Ferritins;
Fever;
Glomerulonephritis, Membranous;
Humans;
Hydrocortisone;
Immunosuppressive Agents;
Leukocytosis;
Lymphatic Diseases;
Middle Aged;
Proteinuria;
Still's Disease, Adult-Onset
- From:Korean Journal of Nephrology
2011;30(4):409-413
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Adult onset Still's disease (AOSD) is a rare systemic inflammatory disease characterized by high spiking fever, leukocytosis, high serum ferritin, salmon-colored rash, arthritis, lymphadenopathy, and hepatosplenomegaly. The etiology of AOSD is obscure. AOSD is diagnosed after exclusion of infection, malignancy and other connective tissue diseases. A 53-year-old female patient with membranous nephropathy was admitted with high fever and leukocytosis. She was taking immunosuppressive agents with low dose steroid and cyclosporine to control of proteinuria caused by membranous nephropathy. She was initially treated with antibiotics, antiviral agent and antifungal agent to control of hidden infection. High spiking fever was sustained for 2 weeks and controlled after hydrocortisone treatment. AOSD was diagnosed according to the criteria of Yamaguchi. It should be considered that AOSD is a cause of high fever in patients treated with immunosuppressive agents.
