Developmental toxicity of exposure to ambient fine particulate matter
10.3969/j.issn.1674-8115.2019.05.021
- Author:
Yun-Jie REN
1
Author Information
1. Shanghai Jiao Tong University School of Public Health
- Publication Type:Journal Article
- Keywords:
Ambient fine particulate matter;
Developmental toxicity;
Epidemiological investigation;
Pregnancy exposure;
Toxic mechanism;
Toxicological study
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2019;39(5):550-556
- CountryChina
- Language:Chinese
-
Abstract:
Domestic and foreign studies have shown that fine particulate matter (PM2.5) pollution is a major factor affecting human health. In addition to the direct impact on the respiratory and cardiovascular systems, PM2.5 exposure during pregnancy can directly affect the growth and development of offspring, manifested as cardiopulmonary dysfunction and cognitive disorder, various adverse pregnancy outcomes, abnormal organ development, and congenital defects. However, the mechanism underlying the developmental toxicity of PM2.5 is still unclear. This article reviews PM2.5-induced developmental toxicity based on epidemiological investigation and toxicological studies, which will provide references for further studies.
