Research progress of secreted protein acidic and rich in cysteine in glaucoma filtering bleb scarring
10.3969/j.issn.1674-8115.2019.06.020
- Author:
Li-Ying LUO
1
Author Information
1. Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Publication Type:Journal Article
- Keywords:
Filtering bleb;
Glaucoma filtration surgery;
Scarring;
Secreted protein acidic and rich in cysteine (SPARC)
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2019;39(6):684-688
- CountryChina
- Language:Chinese
-
Abstract:
Filtering bleb scarring is the main cause of glaucoma filtration surgery failure. Subconjunctival injection of antimetabolites, such as mitomycin and 5-fluorouracil, is widely used clinically to reduce the incidence of scarring, which improves the success rate of the surgery. However, accompanied side effects such as cytotoxicity should not be ignored. Secreted protein acidic and rich in cysteine (SPARC) as a matricellular protein is widely distributed in the eyes, which plays an important role in the process of wound repairing and tissue remodeling. The expression of SPARC is significantly elevated in the mouse model of subconjunctival scarring. Researches suggest that SPARC participates in and regulate the formation of bleb scarring through multiple pathways, therefore it may become a specific new target in the anti-scarring therapy.
