The Effects on Nutrition, Metabolism and Infection by Proton Pump Inhibitors: Unsafe Perspective.
- Author:
Bong Ki CHA
1
;
Chang Hwan CHOI
Author Information
1. Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea. gicch@cau.ac.kr
- Publication Type:Review
- Keywords:
Proton pump inhibitors;
Adverse effects
- MeSH:
Absorption;
Calcium;
Iron;
Pneumonia;
Proton Pump Inhibitors;
Proton Pumps;
Protons;
Vitamin B 12 Deficiency
- From:Korean Journal of Medicine
2011;81(1):17-25
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Proton pump inhibitors (PPI) are very effective drug used frequently in acid-related disorders. Long-term use of PPI is becoming increasingly common, often without appropriate indications. The debate had focused on the adverse effects related to long-term use of PPI during the last years. This article is a detailed review of the evidence on this topic, focusing on the adverse effects of long-term PPI use that have developed the greatest concern; vitamin B12 deficiency, iron deficiency, impaired calcium absorption, bony fracture, hypomagnesemia, increased susceptibility to pneumonia and enteric infections. Although PPIs have been used with a high margin of safety, the clinicians should consider reducing the dose of PPIs and reassessing the treatment duration to prevent adverse effects of PPIs.
