Progress in augmentation therapy mechanism of obsessive compulsive disorder
10.3969/j.issn.1674-8115.2019.08.019
- Author:
Yan-Yan REN
1
Author Information
1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine
- Publication Type:Journal Article
- Keywords:
Antipsychotics;
Augmentation;
Obsessive compulsive disorder (OCD);
Selective serotonin reuptake inhibitor (SSRI)
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2019;39(8):919-922
- CountryChina
- Language:Chinese
-
Abstract:
Administration of selective serotonin reuptake inhibitors (SSRI) is a widely used pharmacotherapeutic approach for obsessive-compulsive disorder (OCD) today. However, nearly half of the OCD patients do not respond to SSRI. It has been shown that some antipsychotic drugs can augment the therapeutic effect of SSRI in the patients with OCD, but the augmentation’s effect is still ineffective for some patients. Therefore, it is of great significance to explore the augmentation’s mechanism for further improvement of the clinical treatment. This article reviews some common used augmentation for OCD and discusses the underlying mechanisms.
