Role of gastrointestinal microbiota in tumorigenesis
10.3969/j.issn.1674-8115.2019.09.023
- Author:
Hai-Yang LU
1
Author Information
1. Department of Hematology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Hematology, le Pôle Sino-Français de Recherchesen Science du Vivant et Génomique
- Publication Type:Journal Article
- Keywords:
Gastrointestinal microbiota;
Genetic instability;
Inflammation;
Malignancy;
Oxidative stress
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2019;39(9):1083-1088
- CountryChina
- Language:Chinese
-
Abstract:
Gastrointestinal microbiota has an important impact on physiological functions of human body. In recent years,the importance of gastrointestinal microbiota in tumorigenesis has emerged. Aberrant location and proportion of microbiota can cause not only carcinogenesis of local epithelia,but also tumorigenesis in submucous tissues or even distant organs. Certain microbes can produce genotoxin or generate reactive oxygen species to cause DNA damage and affect DNA damage repair,which leads to genetic instability and induces cell transformation. Moreover,gastrointestinal microbiota is able to affect the function of host immune system and form an immunosuppressive microenvironment,while some other pathogenic bacteria can cause chronic inflammation and may be involved in tumor immune escape. Based on the above,gastrointestinal microbiota is oncogenic and closely linked to tumorigenesis.
