Efficiency comparison of fasting plasma glucose combined with 1,5-anhydroglucitol and combined with glycated albumin in diabetes mellitus screening
10.3969/j.issn.1674-8115.2019.09.022
- Author:
Hang SU
1
,
2
Author Information
1. Department of Endocrinology and Metabolism,Shanghai Sixth People's Hospital,Shanghai Jiao Tong University, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus
2. Shanghai Clinical Center for Diabetes
- Publication Type:Journal Article
- Keywords:
1,5-anhydroglucitol (1,5-AG);
Diabetes mellitus;
Fasting plasma glucose (FPG);
Glycated albumin (GA);
Screening
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2019;39(9):1077-1082
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To analyze and compare the clinical value of serum 1,5-anhydroglucitol (1,5-AG) with glycated albumin (GA) combined with fasting plasma glucose (FPG),respectively,in screening diabetes mellitus in Chinese population at the risk of diabetes mellitus. Methods: A total of 701 subjects with high risk of diabetes were enrolled in this study,including 324 males and 377 females. All subjects underwent 75 g oral glucose tolerance test (OGTT). Diabetes was diagnosed according to the cut-off points of 2010 American Diabetes Association standards. The sensitivity,specificity and area under ROC curve (AUC) of GA combined with FPG and 1,5-AG combined with FPG in screening diabetes mellitus were analyzed. Results: Among 701 subjects,350 (49.93%) cases were diagnosed as having diabetes mellitus. The sensitivity,specificity,and AUC of 1,5-AG combined with FPG were 84.29%,91.45% and 0.939,respectively. The sensitivity of GA combined with FPG was 77.71%,and the specificity and AUC were 90.88% and 0.932,respectively. There was no significant difference in AUC between the two screening methods (P>0.05),but the sensitivity of 1,5-AG combined with FPG was higher than that of GA combined with FPG (P=0.001). The proportion of the subjects in need of further OGTT judged by 1,5-AG combined with FPG was 27.82%,which was 11.27% lower than that judged by FPG alone,and 2.57% lower than that judged by GA combined with FPG. Conclusion: In Chinese population with high risk of diabetes mellitus,serum 1,5-AG or GA combined with FPG can improve the efficiency of diabetes screening. Compared with GA combined with FPG,1,5-AG combined with FPG may have more clinical value.
