The Association between Albuminuria and Peripheral Arterial Disease in Patients with Type 2 Diabetes Mellitus.
- Author:
Seong Hwan PARK
1
;
Jin Ook CHUNG
;
Dong Hyeok CHO
;
Dong Jin CHUNG
;
Min Young CHUNG
Author Information
1. Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea. mychung@chonnam.ac.kr
- Publication Type:Original Article
- Keywords:
Diabetes mellitus;
Albuminuria;
Peripheral vascular disease
- MeSH:
Albuminuria;
Ankle Brachial Index;
Ankle Joint;
Arteries;
Creatinine;
Diabetes Mellitus;
Diabetes Mellitus, Type 2;
Humans;
Peripheral Arterial Disease;
Peripheral Vascular Diseases;
Retrospective Studies;
Risk Factors
- From:Korean Journal of Medicine
2011;81(1):73-81
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Albuminuria is an early indicator of renal damage in type 2 diabetes mellitus, and has been recognized as a risk factor for peripheral arterial disease (PAD). The aim of this study was to assess the association between albuminuria and PAD in Korean type 2 diabetes patients. METHODS: Our retrospective study included 390 consecutive patients with type 2 diabetes mellitus. The ankle-brachial index (ABI) and toe-brachial index (TBI) were used to assess PAD. The urinary albumin-creatinine excretion ratio (UAE) was evaluated by determining the albumin/creatinine ratio (ACR) in the first voided morning urine sample. RESULTS: Duration of diabetes, serum creatinine levels, and UAE were significantly higher in patients with low ABI scores (< 0.9) than in those with normal ABI scores (> or = 0.9). Age, duration of diabetes, and UAE were significantly higher in patients with low TBI scores (< 0.6) than in those with normal TBI scores (> or = 0.6). Albuminuria was independently associated with low ABI (OR = 1.980, 95% CI = 1.001-3.918). It was also independently associated with low TBI and normal ABI (OR = 3.149, 95% CI = 1.260-7.871). CONCLUSIONS: The results of this study suggest that albuminuria may be associated with PAD, including in arteries distal to the ankle joint.
