Effect of protease activated receptor 2 on colonic motility in diabetes mice
10.3969/j.issn.1674-8115.2019.11.007
- Author:
Yu-Jia LI
1
Author Information
1. Department of Anatomy and Physiology, Shanghai Jiao Tong University College of Basic Medical Sciences
- Publication Type:Journal Article
- Keywords:
Colonic motility;
Diabetes mellitus;
Platelet-derived growth factor receptor α-positive cell (PDGFRα+ cell);
Protease activated receptor 2 (PAR2);
Small conductance calcium-activated potassium channel (SK3 channel)
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2019;39(11):1255-1260
- CountryChina
- Language:Chinese
-
Abstract:
Objective • To observe the effect of protease activated receptor 2 (PAR2) on the colonic motility in diabetic mice and investigate the mechanism. Methods • The mouse model of type 1 diabetes mellitus was established by intraperitoneal injection of streptozotocin. The smooth muscle strips and segments of colons were isolated. The effects of PAR2 agonist on colonic motility were observed by muscle strip tension contraction and colonic migrating motor complex experiments. The effect of small conductance calcium-activated potassium channel (SK3 channel) antagonist on it was also observed. Results • PAR2 agonist inhibited colonic motility and colonic smooth muscle was more sensitive to PAR2 agonist in diabetic mice. PAR2 agonist-induced inhibition was inhibited by SK3 channel antagonist. Conclusion • PAR2 activity in diabetic mice colons is significantly enhanced, which may inhibit colonic motility through SK3 channel.
