Recent advances in role of monocyte-macrophage in anti-neutrophil cytoplasmic antibody associated vasculitis
10.3969/j.issn.1674-8115.2020.01.020
- Author:
Xiao-Ning AN
1
Author Information
1. Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Publication Type:Journal Article
- Keywords:
ANCA associated vasculitis;
Anti-neutrophil cytoplasmic antibody (ANCA);
Macrophage;
Monocyte
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2020;40(1):123-127
- CountryChina
- Language:Chinese
-
Abstract:
Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) constitues a group of autoimmune diseases with poor prognosis. Inflammation and fibrinoid necrosis of the small vessels are the pathological features of the disease, and many organs and systems can be involved. Monocyte-macrophages are important to innate immune system. Monocyte-macrophage can respond rapidly to inflammation and participate in the progression of AAV. Recently, the role of monocyte-macrophage in AAV has been studied with great detail. This article reviews recent research progress of monocyte-macrophage in AAV so as to further understand the disease.
