Research progress of the mechanism and treatment of macrophage in spinal cord injury repair
10.3969/j.issn.1674-8115.2020.01.019
- Author:
Jun-Qing LIN
1
Author Information
1. Department of Orthopaedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University
- Publication Type:Journal Article
- Keywords:
Macrophage;
Neuroregenerations;
Self-repair;
Spinal cord injury;
Therapy
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2020;40(1):118-122
- CountryChina
- Language:Chinese
-
Abstract:
Self-repair has been initiated after spinal cord injury (SCI). Unlike wound healing, the self-regeneration of spinal cord is incomplete and insufficient. Many studies show that there are a lot of cells and factors active in self-repair of SCI. Inflammatory is a hard problem for us to face in SCI. Over-inflammatory will cause secondary damage to the spinal cord and the capacity of self-repair. In the inflammatory environment, Many kinds of research evidence prove that macrophage pays a vital role in the over inflammatory with damaging the self-repair of SCI. Thus, targeting macrophage in spinal cord injury will hopefully become a method in SCI repair. This review clarifies the function and mechanism of macrophage in SCI repair and the new targeting macrophage methods in recovering the self-repair capacity of SCI.
