Meta-analysis of effect and safety of repetitive transcranial magnetic stimulation on patients with schizophrenia
10.3969/j.issn.1674-8115.2020.01.013
- Author:
Yan HUANG
1
Author Information
1. Department of Psychiatry, North China University of Technology
- Publication Type:Journal Article
- Keywords:
Meta-analysis;
Repetitive transcranial magnetic stimulation(rTMS);
Schizophrenia
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2020;40(1):81-88
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy and safety of repetitive transcranial magnetic stimulation (rTMS) for schizophrenia by meta-analysis, and provid evidence support for clinical treatment of schizophrenia. Methods:Randomized controlled trials of rTMS and schizophrenia were searched on Embase, PubMed, Cochrane Library, CNKI, Wanfang and VIP. The quality of the included literature was controlled and meta-analysis was performed with Stata 15.1 software. Results:Seventeen studies were enrolled, including 486 patients in the stimulation group and 436 in the control group. rTMS was effective in treating patients with schizophrenia (OR=3.32, 95% CI 1.93-5.70, Z=4.35, P=0.000); rTMS treatment was effective for overall condition and negative symptoms of patients with schizophrenia (SMD=-0.33, 95% CI -0.58--0.08, Z=2.61, P=0.009; SMD=-0.41, 95% CI -0.65--0.17, Z=3.31, P=0.001), and ineffective for positive symptoms (P=0.755). There was no significant difference in adverse reactions between the two groups (P=0.732). Subgroup analysis revealed that only high frequency (10 Hz) stimulation and treatment for 4 weeks could achieve therapeutic effects. Conclusion:rTMS is effective in treating negative symptoms of patients with schizophrenia and has high therapeutic safety, but it is ineffective for positive symptoms.
