Research progress on the promoting effect of interleukin-11 on tumors
10.3969/j.issn.1674-8115.2020.04.023
- VernacularTitle: 白细胞介素 -11对肿瘤促进作用的研究进展
- Author:
De-Shen PAN
1
Author Information
1. Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University
- Publication Type:Journal Article
- Keywords:
Interleukin-11 (IL-11);
JAK/STAT pathway;
PI3K/AKT pathway;
TGF-β/Smad pathway;
Tumor microenvironment
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2020;40(4):548-553
- CountryChina
- Language:Chinese
-
Abstract:
According to the lastest statistics, the overall morbidity and mortality of cancer in China still show an upward trend compared with historical data. An in-depth understanding of the molecular mechanisms of tumorigenesis and development is important to formulate future treatment strategies. Interleukin 11 (IL-11) is a member of cytokines that traditionally promote megakaryocyte maturation and regulate immune activity. In recent years, the promoting effect of IL-11 on tumor has been gradually discovered. This review mainly expounds that IL-11 is regu-lated by transforming growth factor-β/drosophila mothers against decapentaplegic protein (TGF-β/Smad) pathway, and may play a role in tumor-igenesis, drug resistance, metastasis and tumor microenvironment through signal transduction pathways such as Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway and phosphatidylinositol 3 kinase/protein kinase B (PI3K/AKT) pathway, and explores the application prospect of interfering IL-11 signal transduction in tumor therapy.
