Effect of RNA N6-methyladenosine on immunoregulation
10.3969/j.issn.1674-8115.2020.04.020
- VernacularTitle: N6- 腺苷酸甲基化RNA修饰在免疫调控中的作用
- Author:
Xu-Ying ZHU
1
Author Information
1. Department of Nephrology, Renji hospital, Shanghai Jiao Tong University School of Medicine
- Publication Type:Journal Article
- Keywords:
Demethylase;
Immune;
Methyltransferase;
N6-methyladenosine;
RNA modification
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2020;40(4):534-538
- CountryChina
- Language:Chinese
-
Abstract:
N6-methyladenosine (m6A) is the most prevalent and abundant post-transcriptional RNA modification in eukaryotes. m6A is a dy-namic and reversible process catalyzed by m6A methyltransferase complex and demethylase. m6A is involved in the regulations of gene expres-sion and biological processes. Recently, researches have discovered that m6A plays a vital role in the differentiation and regulation of immune cells, which could provide a new idea for the research and therapy of immune-related diseases. The present article reviews the recent progresses of m6A in immunoregulation.
