Study on the prognosis of intravenous thrombolysis in patients with ischemic stroke by thyroid-related hormones and antibodies
10.3969/j.issn.1674-8115.2020.04.010
- VernacularTitle: 甲状腺相关激素及抗体与缺血性脑卒中患者静脉溶栓的预后相关性研究
- Author:
Jing-Han XU
1
Author Information
1. Department of Neurology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
- Publication Type:Journal Article
- Keywords:
Functional outcome;
Intracranial hemorrhage;
Intravenous thrombolysis;
Ischemic stroke;
Thyroid-related hormones
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2020;40(4):478-483
- CountryChina
- Language:Chinese
-
Abstract:
Objective : To explore the association between thyroid-related hormones and antibodies and the prognosis of ischemic stroke pa-tients treated with intravenous thrombolysis using recombinant tissue plasminogen activator (rt-PA). Methods ¡¤ A total of 213 consecutive pa-tients with ischemic stroke who underwent rt-PA intravenous thrombolysis in the Department of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, were retrospectively included from May 2012 to August 2018. Thyroid-related hormones and antibodies were tested on admission, and assessment of intracranial hemorrhage (ICH) was conducted 24 hours after thrombolysis. Func-tional outcomes were assessed by modified Rankin Scale (mRS) after 3 months of follow-up. The relationship between thyroid-related hormones and antibodies and the prognosis (including functional outcome and ICH) was analyzed by logistic regression analysis. Results ¡¤ In univariate regression analysis, free triiodothyronine (fT3), total triiodothyronine, (tT3) and total thyroxine (tT4) levels were associated with poor functional prognosis (P=0.000, P=0.028, P=0.000) and fT3, and free thyroxine (fT4) levels were associated with ICH (P=0.008, P=0.014). However, after adjustment for other variables, low fT3 levels were independently associated with poor prognosis (OR=0.35, 95%CI 0.138-0.890, P=0.027), and both fT3 and fT4 levels had nothing to do with ICH. In addition, fT3 was negatively correlated with stroke severity (r=-0.291, P=0.000). Con-clusion ¡¤ Low fT3 levels are associated with stroke severity and functional outcome.
