Evaluation of physical and neurocognitive development of infants conceived from frozen embryo transfer
10.3969/j.issn.1674-8115.2020.06.004
- VernacularTitle: 冰冻胚胎移植子代幼儿的体格和神经认知发育评估
- Author:
Ze-Han DONG
1
Author Information
1. Shanghai Key Laboratory of Embryo Original Diseases, Department of Assisted Reproduction, The International Peace Maternity & Child Health Hospital, Shanghai JiaoTong University School of Medicine
- Publication Type:Journal Article
- Keywords:
Frozen embryo transfer (FET);
In vitro fertilization (IVF);
Neurocognitive development;
Physical growth
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2020;40(6):719-725
- CountryChina
- Language:Chinese
-
Abstract:
Objective • To evaluate the physical and neurocognitive development of infants conceived from frozen embryo transfer (FET). Methods • Two hundred and forty-eight infants (1.5-4 years old) conceived from FET and natural conception (NC) were recruited as the follow-up cohort of FET offspring, and their physical and neurocognitive development were followed up and evaluated. Multiple Logistic regression analysis was used to assess the potential risk of cognitive retardation in FET offspring. Results • There was no significant difference in composition ratio of Z score for height, weight and body mass index between the FET group and the NC control group. Multiple Logistic regression analysis showed that compared with the NC control group, the risk of neurocognitive development abnormalities and retardation was higher in the FET group, especially in fine motor (OR=3.01, 95%CI 1.48-6.11) and social development domains (OR=3.76, 95%CI 1.63-8.69); and in the FET group, the social development risk of female infants was higher than that of male infants. Conclusion • FET may exert a negative impact on the early neurocognitive development of infants.
