Application of optical coherence tomography angiography to evaluation of clinical effect of antivascular endothelial growth factor agents on wet age-related macular degeneration
10.3969/j.issn.1674-8115.2020.08.015
- VernacularTitle: 光学相干断层扫描血管成像在抗血管内皮生长因子药物治疗湿性年龄相关性黄斑变性效果评价中的应用
- Author:
Qiong ZHANG
1
Author Information
1. Department of Ophthalmology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Publication Type:Journal Article
- Keywords:
Age-related macular degeneration (AMD);
Anti-vascular endothelial growth factor (VEGF) agent;
Optical coherence tomography angiography (OCTA)
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2020;40(8):1091-1097
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To apply optical coherence tomography angiography (OCTA) to evaluate the clinical effects of intravitreal injection of antivascular endothelial growth factor (VEGF) agents on wet age-related macular degeneration (AMD). Methods: The 31 eyes of 31 wet AMD patients in the Department of Ophthalmology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine from April 2018 to December 2018 were included. These patients received monthly intravitreal injection of anti-VEGF agents for three consecutive months. The best-corrected visual acuity (BCVA) before and 1, 2 and 3 months after first injection was compared. The macular fovea thickness and choroidal neovascularization (CNV) area at different time points before and after treatment were detected by OCTA and compared. Results: The baseline BCVA (logarithm of the minimum angle of resolution) of the included patients was 0.93±0.43, and the BCVA was significantly improved after treatment (P<0.05). The results of OCTA showed that before treatment the inner limiting membrane-retinal pigment epithealium thickness and inner limiting membrane-retinal pigment epithelial fit thickness were (329.03±110.73) μm and (468.84±209.50) μm, respectively, and they both decreased significantly after treatment (P<0.05). The CNV area before treatment was (4.78±3.24) mm2, and it decreased gradually with time after treatment (P<0.05). Conclusion: Intravitreal injection of anti-VEGF agents can reduce macular edema and inhibit CNV in the wet AMD patients. OCTA can be used to evaluate the efficacy of intravitreal injection of anti-VEGF agents in the treatment of wet AMD.
