Study on Methodology Re-evaluation for Systematic Review/Meta-analysis of Antidepressants in the Treatment of Post-stroke Depression
- VernacularTitle:抗抑郁药物治疗卒中后抑郁系统评价/Meta分析的方法学再评价研究
- Author:
Yue GUAN
1
;
Guiping GUO
1
;
Jingwen WANG
1
;
Mingming WANG
1
;
Fei MOU
1
;
Yi QIAO
1
;
Qiongge LI
2
Author Information
1. Dept. of Pharmacy，the First Affiliated Hospital of Air Force Military Medical University，Xi’an 710032，China
2. Dept. of Pharmacy，Xi’an Municipal Forth Hospital，Xi’an 710004，China
- Publication Type:Journal Article
- Keywords:
Post-stroke depression;
AMSTAR scale;
Methodology;
Quality re-evaluation;
Systematic evaluation;
Meta-analysis
- From:
China Pharmacy
2020;31(24):3036-3041
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To re-evaluate t he methodology quality of published systematic review/Meta-analysis of antidepressants in the treatment of post-stroke depression. METHODS ：Retrieved from Cochrane Library ，PubMed，Embase， SinoMed，CNKI，Wanfang database ，VIP，CBM and other databases ，systematic review/Meta-analysis of antidepressants in the treatment of post-stroke depression were collected during the inception to Dec. 2019. After literature screening and data extraction ， methodology quality of included literatures were evaluated by using the AMSTAR scale. RESULTS ：A total of 33 systematic reviews/Meta-analysis were included ，involving 523 RCTs and 41 020 patients. Average score of AMSTAR methodological quality evaluation was 6.76. Citalopram ，duloxetine and paroxetine were effective for the therapy of post-stroke depression ，but the conclusions about the effectiveness among antide-pressants were not consistents. The ADR incidence of Paroxetine was low. It was not clear that sertraline and citalopram may improve the neurological function of patients. CONCLUSIONS ：The methodological quality of systematic review/Meta-analysis of antidepressants in the treatment of post-stroke depression is medium ，and the conclusions about the effectiveness of antidepressants ，improvement of daily life ability and the recovery of neurological function are still controversial.
